André W. Phillips, Ph.D.
Associate Staff Scientist
2014-present Associate Staff Scientist, Program in Neuroscience, Hussman Institute for Autism, Baltimore, MD
2009-2013 Research Scientist, Hugo W. Moser Research Institute at Kennedy Krieger, Johns Hopkins Medical School, Baltimore, MD
2006-2008 Postdoctoral IRTA Fellow, The National Institutes of Health, Bethesda, MD
2000-2006 Ph.D. Neuroscience, Howard University, Washington, D.C.
1996-2005 Pre-Doctoral IRTA Fellow, The National Institutes of Health, Bethesda, MD
1996-1999 M.S. Biology, Howard University, Washington, D.C.
1991-1995 B.S. Biology, Howard University, Washington, D.C.
The state of the microenvironment of CNS tissue affects an array of cellular cascades that can include motility, polarity, adhesion and even endocytosis and exocytosis. The cell response to perturbations in its environment may be affected by genetic and/or epigenetic preconditions that may confer heightened vulnerability. These conditions may impair recovery from perturbations and could be significant in the etiology of autism. We will use iPSCs to develop in vitro models that recapitulate the autistic cellular phenotype. This platform will be interrogated for the effects of autism-related gene mutations on typical cellular functions to provide a link between gene expression and altered cellular function. A combination of next-generation screening technologies such as ArrayScan, Multi-Electrode Array and RNASeq will be part of the approach to decipher this link. The insights gained into the molecular pathways will inform development of novel therapies and identification of molecular diagnostic markers.