Krishna Subramanian, Ph.D.
Postdoctoral Research Fellow
2015- Present Postdoctoral Fellow, Program in Neuroscience, Hussman Institute for Autism
2014-2015 Postdoctoral Fellow, Baylor College of Medicine, Houston, TX
2014 Ph.D. Neurobiology, University of Pittsburgh, Pittsburgh, PA
2007 B.Tech. Biotechnology, Anna University, Chennai, India
Understanding brain functions under neurotypical conditions to help develop treatment for non-neurotypical circumstances.
Using a combination of techniques to understand changes in brain circuits in individuals with autism to develop potential new treatment options.
My research has focused on understanding the functioning of the brain through understanding how it functions in disorders. My work involved using novel neurotrophic factors and developing them for translation into possible treatments for neurodegenerative diseases like Parkinson’s disease (PD). The neurotrophic factors (CDNF and NRTN mutants) that I tested in a unilateral non-human primate MPTP model of PD was successful in recovering some of the symptoms in the disease model. These neurotrophic factors are currently under consideration for treating Parkinson’s disease patients. Understanding the functioning of neural circuits in normal behavior, conditions of neurodegeneration, and in neurodevelopmental conditions such as autism can provide insight into development of treatment options.
Subramanian K, Rockcastle N, Zhang Z, Cameron J, Penn R, Saarma MA. Heparin non-binding mutant form of Neurturin rescues dopaminergic system in a monkey model of Parkinson’s disease (in preparation)
Subramanian K, Rockcastle N, Zhang Z, Ryan N and Cameron J. Assessment of Sleep Disorders in a unilateral low dose MPTP model of Parkinson’s disease. (Submission phase)
Subramanian K, Dokka K, Ma W, Angelaki DA. Bayesian integration of audio-visual discrimination in autism spectrum disorder (in preparation)
Subramanian K*, Dokka K*, Ma W, Angelaki DA. Causal inference deficits in autism spectrum disorder (in preparation)
Subramanian K*, Cameron J*, Rockcastle N, Zhang Z, Penn R, Saarma MA, Ryan N. Increased Daytime Sleep in a Unilateral Nonhuman Primate Model of Parkinson’s Disease: Treatment with a Novel Neurotrophic Factor, APSS, Sleep 2014
Subramanian K*, Adam C, Dettmer AM, Doyle A, Liu T, Culver S, Benji S, Ragoza M, Brandon C, Morgan J, Pyrdek D, Rockcastle N, Ryan ND, Zhang Z, Penn R, Saarma M, Cameron JL. Deficits in motivation, increased anxiety, and increased daytime sleepiness in a nonhuman primate MPTP model of Parkinson’s disease, Society for Neuroscience, SfN 2015