Yue Wang, Ph.D., M.D.
Postdoctoral Research Fellow
2015-present Postdoctoral Fellow, Hussman Institute for Autism, Baltimore, MD
2013-2014 Research Fellow, School of Biological Sciences, Nanyang Technological University, Singapore
2008-2013 Ph.D., Yong Loo Lin School of Medicine, National University of Singapore
2006-2007 Research Assistant, National University of Singapore, Singapore
2003-2006 M.Sc., Neurophysiology, Dalian Medical University, China
1998-2003 M.D., Clinical Medicine, Dalian Medical University, China
My current research aims to clarify the functions of cadherin family members in the development of brain circuits that are closely related to autism. I will also explore the underlying signaling pathways and molecular mechanisms.
My previous research was focused on regulation of the assembly and maintenance of inhibitory neural circuits in the cerebellum. The development and function of most regions in the nervous system rely on the precise balance between excitatory and inhibitory neurotransmitter systems. Although inhibitory interneurons comprise only a small fraction of all neurons in the brain, abnormalities in their development and the subsequent imbalance between excitation and inhibition of the brain can lead to neurological and neuropsychiatric conditions such as autism, epilepsy, and schizophrenia. Using genetics and imaging tools, I have studied the structure and function of inhibitory synapses in the cerebellum.
Wang Y, Ali Y, Lim CY, Hong W, Pang ZP, Han W. Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation. Biochem J. 2014 Mar 15; 458(3):491-8. (PMID: 24405299)
Lou PH, Gustavsson N, Wang Y, Radda GK, Han W. Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion. PLoS One. 2011; 6(10):e26671. (PMID: 22046328)
Gustavsson N, Wang Y, Kang Y, Seah T, Chua S, Radda GK, Han W. Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice. Diabetologia. 2011 Jul; 54(7):1824-30. (PMID:21424898)
Gustavsson N, Wang X, Wang Y, Seah T, Xu J, Radda GK, Südhof TC, Han W. Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. PLoS One. 2010 Nov 9; 5(11):e15414. (PMID:21085706)