Shiyong Huang, Ph.D.
2015-present Adjunct Assistant Professor, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD
2014-present Investigator, Program in Neuroscience, Hussman Institute for Autism, Baltimore, MD
2013-2014 Associate Research Scientist, Johns Hopkins University, Baltimore, MD
2010- 2013 Assistant Research Scientist, Johns Hopkins University, Baltimore, MD
2006-2010 Postdoctoral Fellow, Johns Hopkins University, Baltimore, MD
2006 Ph.D. Neurobiology, Chinese Academy of Sciences, Shanghai, China
2001 B.S. Biochemistry, Wuhan University, Wuhan, China
Employing a combination of cutting-edge approaches, including neural computational, electrophysiological, optogenetic, and imaging, we aim to measure and manipulate neural connectivity within genetically-defined circuits. We expect to confirm causal links between these circuits and autism behavior. Then we will use mouse models to develop potential treatments.
My research has focused on the development of the input and output connectivity of GABAergic interneurons in rodent visual cortex. My work revealed that endocannabinoids control the maturation of GABAergic connectivity during the critical period of visual cortical development. Moreover, I developed strategies to successfully reopen the window for visual cortical plasticity in adults via reduction of inhibition and neuromodulators. Understanding the regulation of brain plasticity provides essential insight for translational developments, such as therapeutics for autism.
Park SM, Plachez C#, Huang S#. Sex-dependent motor deficit and increased anxiety-like states in mice lacking autism-associated gene Slit3. Front. Behav. Neurosci. 2018, 12: 261. (#Co-corresponding author)
Huang S#, Bridi M, Kirkwood A#. Dynamic recovery from depression enables rate encoding in inhibitory synapses. 2018. bioRxiv 379081. (#Co-corresponding author)
Bridi M, Park SM, Huang S. Developmental disruption of GABAAR-meditated inhibition in Cntnap2 KO mice. eNeuro 2017, 4(5): 0162-17. (PMID: 28966979)
Gao M*, Whitt JL*, Huang S*, Lee A, Mihalas S, Kirkwood A, Lee HK. Experience-dependent homeostasis of “noise” at inhibitory synapses preserves information coding in adult visual cortex. Phil. Trans. R. Soc. B. 2017, 372(1715). (*Equal contribution) (PMID: 28093550)
Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief dark exposure reduces tonic inhibition in visual cortex. J. Neurosci. 2015, 35: 15916-15920. (PMID: 26631472)
Huang S, Rozas C, Treviño M, Contreras J, Yang S, Song L, Yoshika T, Lee HK, Kirkwood A. Associative hebbian synaptic plasticity in primate visual cortex. J. Neurosci. 2014, 34: 7575-7579. (PMID: 24872561)
Huang S, Huganir RL, Kirkwood A. Adreneric gating of Hebbian spike-time dependent plasticity in cortical interneurons. J. Neurosci. 2013, 33: 13171–13178. (PMID: 23926270)
Gu Y*, Huang S*, Chang CM, Worley P, Kirkwood A, Quinlan E. Obligatory role for the immediate early gene NARP in critical period plasticity. Neuron 2013, 79: 335-346. (*Equal contribution) (PMID: 23889936)
Huang S*,Treviño M*, He K*, Ardiles A, De Pasquale R, Guo Y, Palacios A, Huganir RL, Kirkwood A. Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron 2012, 73: 497-510. (*Equal contribution) (PMID: 22325202)
Huang S*, Gu Y*, Quinlan E, Kirkwood A. A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure. J. Neurosci. 2010, 30: 16636-16642. (*Equal contribution) (PMID: 21148002)
Jiang B*, Huang S*, De Pasquale R, Millman D, Song L, Lee HK, Tsumoto T, and Kirkwood A. The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 2010, 66: 248-259. (*Equal contribution) (PMID: 20435001)